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ISD Scotland better information, better decisions, better health


Scottish Clinical Trials Research Unit

NHS National Services Scotland ISD Scotland & NHS National Services Scotland

Anglo Celtic Collaborative Oncology Group(ACCOG)

The initial purpose was to test the then widely held belief that extremely high doses of chemotherapy could significantly increase the curability of aggressive breast cancer if given at an early stage.In the USA in the early 1990's, the commonest condition for which bone marrow transplantation was being used was breast cancer, all the evidence then coming from uncontrolled studies and an assumption that more was better (qv radical mastectomy, The Halsted Era 1916-1980).

The ACCOG trial ran for 5 years across many UK and a couple of international collaborating centres and compared best standard chemotherapy against experimental high dose intensification supported by peripheral progenitor white cell reinfusion after induction therapy. The trial proved no benefit for high dose therapy but brought together an enthusiastic group of investigators who set out to conduct further trials in early and advanced breast cancer up to the present time.

The group has routinely met at one of several UK centres on a rotational 6 monthly basis over the last 15 years or so and has set up trials of preoperative chemotherapy, metastatic breast cancer chemotherapy, treatment of older women, protection of ovarian failure due to chemotherapy and examining the role of GCSF to maintain adequate dose intensity of chemotherapy in early stage disease.

We have had very good relations with the pharmaceutical industry over the years and have encouraged joint meetings to allow pipeline developments to be shared with investigators by Industry.

Joint Chairs

Prof John Crown -
Prof Robert Leonard -


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Gyle Square
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